MNS (3,4-Methylenedioxy-β-nitrostyrene) Clinical Trials

Size	Price	Qty
50mg	USD 147
200mg	USD 247

Clinical Trials

Numerous clinical trials evaluate diverse therapeutic applications across oncology, neurology, and metabolic disease, addressing conditions such as melanoma, nasal polyps, post-cardiac arrest brain injury, diabetes, bipolar depression, and obesity. Spanning Phase 1 through Phase 4 alongside non-phase interventional evaluations, these studies feature recruitment statuses ranging from active and recruiting to completed, terminated, or withdrawn. Trial sponsors represent a diverse mix of commercial pharmaceutical companies like GlaxoSmithKline, academic institutions including Johns Hopkins University, and international research organizations.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07416552	RECRUITING	Metastatic Colorectal Cancer	Hoffmann-La Roche	2026-09-08	PHASE1
NCT07192952	RECRUITING	Left Ventricular Systolic Dysfunction; Heart Failure (Pediatric)	Bayer	2026-06-01	PHASE3
NCT04844606	RECRUITING	Ulcerative Colitis; Ulcerative Colitis Chronic; Inflammatory Bowel Diseases; Crohn's Disease	Eli Lilly and Company	2021-05-26	PHASE3
NCT07001618	RECRUITING	NSCLC (Advanced Non-small Cell Lung Cancer)	Gustave Roussy, Cancer Campus, Grand Paris	2025-11-17	PHASE2
NCT06655649	SUSPENDED	Obstructive Sleep Apnea; Sleep	Johns Hopkins University	2025-01-29	PHASE1
NCT07129993	RECRUITING	Urothelial Cancer; Bladder Cancer	Daiichi Sankyo	2025-09-26	PHASE2; PHASE3
NCT07464951	RECRUITING	Acute Myeloid Leukemia (AML)	Stephan Grupp MD PhD	2026-05-14	PHASE1
NCT03633708	RECRUITING	Secondary Hyperparathyroidism; Chronic Kidney Disease	Amgen	2019-04-29	PHASE3
NCT07775300	NOT_YET_RECRUITING	Depressive Disorder, Major	Eli Lilly and Company	2026-08	PHASE3
NCT07003984	RECRUITING	Chikungunya Virus	Bavarian Nordic	2025-06-05	PHASE3
NCT06903884	RECRUITING	Vernal Keratoconjunctivitis	The University of Hong Kong	2026-02-09	PHASE3
NCT06497465	RECRUITING	Tuberculosis; HIV	Johns Hopkins University	2025-09-18	PHASE3
NCT07715084	NOT_YET_RECRUITING	Gaucher Disease Type 3	Azafaros B.V.	2026-09-28	PHASE2
NCT05865743	RECRUITING	Esophageal Cancer	Radboud University Medical Center	2024-10-21	PHASE3
NCT06696690	NOT_YET_RECRUITING	Median Nerve; Coma; Post Cardiac Arrest Brain Injury	Tang Ziren	2025-05-01
NCT07472491	RECRUITING	Known or Highly Suspected Central Nervous System (CNS) Lesion; Known or Highly Suspected Body (Excluding CNS) Lesion	GE Healthcare	2026-04-01	PHASE2; PHASE3
NCT07283484	RECRUITING	Acute Urinary Retention; Benign Prostate Obstruction; Benign Prostate Hyperplasia; Benign Prostate Hypertrophy(BPH)	Liselot Ribbert	2025-08-21
NCT06058455	RECRUITING	Sexual Assault	University of Maryland, College Park	2023-10-02
NCT06979336	RECRUITING	Ulcerative Colitis	Genentech, Inc.	2025-09-29	PHASE2
NCT05648214	RECRUITING	Healthy Volunteers; Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)	Regeneron Pharmaceuticals	2022-12-27	PHASE1; PHASE2
NCT07668778	NOT_YET_RECRUITING	Cirrhosis; Bowel Preparation	Hospital do Divino Espírito Santo de Ponta Delgada	2026-08-01	PHASE3
NCT06087952	ACTIVE_NOT_RECRUITING	Venous Thromboembolism; Venous Thromboses; Pulmonary Embolism; Deep Vein Thrombosis	Leiden University Medical Center	2021-06-18
NCT05973773	ACTIVE_NOT_RECRUITING	Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation	Taiho Oncology, Inc.	2023-12-18	PHASE3
NCT04771416	SUSPENDED	Leukodystrophy, Globoid Cell	Gemma Biotherapeutics	2022-02-24	PHASE1; PHASE2
NCT05338190	RECRUITING	Primary Immune Thrombocytopenia (ITP)	Assistance Publique - Hôpitaux de Paris	2022-11-14	PHASE3
NCT07595458	RECRUITING	Antiviral Drug	Just-Evotec Biologics	2026-06-23	PHASE1
NCT07112443	RECRUITING	Congenital Pseudarthrosis of Tibia	Novadip Biosciences	2025-09-02	PHASE3
NCT07584304	NOT_YET_RECRUITING	Healthy Subjects	Yuhan Corporation	2026-07-10	PHASE1
NCT04607954	ACTIVE_NOT_RECRUITING	Platinum-Resistant Lung Small Cell Carcinoma; Platinum-Sensitive Lung Small Cell Carcinoma; Recurrent Extensive Stage Lung Small Cell Carcinoma; Refractory Extensive Stage Lung Small Cell Carcinoma	Mayo Clinic	2020-12-04	PHASE2
NCT06589765	COMPLETED	Type 2 Diabetes	Shandong Suncadia Medicine Co., Ltd.	2024-09-27	PHASE3
NCT05815485	ACTIVE_NOT_RECRUITING	COVID-19	The University of Texas Medical Branch, Galveston	2023-05-04	PHASE2; PHASE3
NCT03902184	COMPLETED	Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Mycosis Fungoides/Sezary Syndrome	Innate Pharma	2019-05-22	PHASE2
NCT06201247	RECRUITING	Acute Myeloid Leukemia, in Relapse; Acute Myeloid Leukemia Refractory	Peking University People's Hospital	2023-12-30	EARLY_PHASE1
NCT05993858	NOT_YET_RECRUITING	Head and Neck Squamous Cell Carcinoma; Neoadjuvant Therapy	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	2023-10-20	PHASE2
NCT06412185	UNKNOWN	Alzheimer Disease	Keymed Biosciences Co.Ltd	2024-05-28	PHASE1
NCT02531126	COMPLETED	Ulcerative Colitis	Celgene	2015-12-02	PHASE3
NCT06223386	UNKNOWN	Overweight and Obesity	Academia Sinica, Taiwan	2024-02-26
NCT07138131	COMPLETED	Omega 3; Treatment; Inappropriate Sinus Tachycardia	Benha University	2023-10-01
NCT05711030	UNKNOWN	Breast Neoplasms; Breast Neoplasm Female; Cancer, Breast; Breast Cancer	Ciusss de L'Est de l'Île de Montréal	2022-11-04
NCT05457517	UNKNOWN	Advanced Solid Tumors	Shanghai YingLi Pharmaceutical Co. Ltd.	2022-09-24	PHASE1; PHASE2
NCT06337071	UNKNOWN	Meningococcal Meningitis	Aimei Vacin BioPharm (Zhejiang) Co., Ltd.	2024-03-20	PHASE2
NCT06233071	UNKNOWN	Healthy Subjects	Bio-innova Co., Ltd	2024-02-13	PHASE1
NCT04951115	TERMINATED	Small-cell Lung Cancer	Weill Medical College of Cornell University	2021-07-12	PHASE2
NCT05119855	COMPLETED	Papillomavirus Infections; Coronavirus Disease (COVID-19)	Merck Sharp & Dohme LLC	2022-03-28	PHASE3
NCT05375214	COMPLETED	Bipolar Depression; Bipolar I Disorder	Johns Hopkins University	2023-03-03
NCT05350163	TERMINATED	Lymphoid Leukemia, Acute; Myeloid Malignancy; Plasma Cell Tumor	Guenther Koehne	2022-04-05	PHASE1
NCT05134649	COMPLETED	Platysma Prominence	AbbVie	2021-11-16	PHASE3
NCT04005716	COMPLETED	Small Cell Lung Cancer	BeiGene	2019-07-22	PHASE3
NCT03397706	COMPLETED	Epstein-Barr Virus-Associated Lymphoma; Lymphoproliferative Disorders	Viracta Therapeutics, Inc.	2018-03-29	PHASE1; PHASE2
NCT04209855	COMPLETED	Epithelial Ovarian Cancer; Peritoneal Cancer; Fallopian Tube Cancer	AbbVie	2019-12-31	PHASE3
NCT04903847	UNKNOWN	Hiv; HIV Infections; HIV Lipodystrophy; Osteoporosis; Renal Insufficiency; Weight Gain; Obesity	Thomas Benfield	2021-02-02	PHASE4
NCT05149313	COMPLETED	Dermatitis, Atopic; Eczema	Almirall, S.A.	2021-12-23	PHASE3
NCT05532358	COMPLETED	Healthy Volunteers	MODAG GmbH	2022-09-12	PHASE1
NCT03964116	COMPLETED	Cancer; Adolescent Behavior; Young Adult	Institut Curie	2018-12-07
NCT05711810	COMPLETED	Severe Acute Respiratory Syndrome-related Coronavirus; Renal Dialysis; Vaccines; Myocarditis Allergic; Infection Viral	Yang I. Pachankis	2023-01-02	PHASE4
NCT04398433	COMPLETED	Respiratory Papillomatosis	Inovio Pharmaceuticals	2020-10-07	PHASE1; PHASE2
NCT03719664	UNKNOWN	HIV-1-infection	Frontier Biotechnologies Inc.	2018-12-17	PHASE2
NCT05025735	UNKNOWN	Metastatic Breast Cancer; HER2-negative Breast Cancer	Saint Luke's Health System	2021-08-25	PHASE2
NCT03845348	UNKNOWN	Scalp Dermatitis	Sao Thai Duong Joint Stock Company	2019-05-22	PHASE3
NCT05568693	UNKNOWN	Corona Virus Disease 2019(COVID-19)	Yu Qin	2022-09-21
NCT04927884	TERMINATED	Advanced Triple Negative Breast Cancer	ImmunityBio, Inc.	2021-09-08	PHASE1; PHASE2
NCT04700332	RECRUITING	Prostate Cancer	Hoag Memorial Hospital Presbyterian	2021-02-01	PHASE2
NCT05372016	COMPLETED	HPV Infections; Cervical Cancer; Vulvar Cancer; Vaginal Cancer; CIN1; CIN2; CIN3; VaIN1; VaIN2; VaIN3; Genital Wart; VIN 1; VIN 2; VIN 3; AIS	Shanghai Bovax Biotechnology Co., Ltd.	2020-09-19	PHASE3
NCT04701606	UNKNOWN	Covid19	Shin Poong Pharmaceutical Co. Ltd.	2021-03-29	PHASE2; PHASE3
NCT05254548	COMPLETED	Healthy	Idorsia Pharmaceuticals Ltd.	2022-02-18	PHASE1
NCT03168464	TERMINATED	Non Small Cell Lung Cancer Metastatic	Weill Medical College of Cornell University	2017-10-09	PHASE1; PHASE2
NCT02958111	UNKNOWN	Nasopharyngeal Carcinoma	Sun Yat-sen University	2017-01	PHASE3
NCT03650478	COMPLETED	Pediatric Respiratory Diseases; Bronchiolitis; Infant Respiratory Distress Syndrome	St. Justine's Hospital	2018-10-01
NCT04557306	COMPLETED	Solid Tumor	CHABiotech CO., Ltd	2020-09-21	PHASE1
NCT04134728	COMPLETED	Arthritis, Rheumatoid	GlaxoSmithKline	2019-10-31	PHASE3
NCT06034626	COMPLETED	MGD-Meibomian Gland Dysfunction	Second Affiliated Hospital, Zhejiang University, School of Medicine	2020-11-03	PHASE3
NCT03333174	COMPLETED	Infant,Premature	University of Alabama at Birmingham	2018-04-09
NCT03336333	ACTIVE_NOT_RECRUITING	Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma	BeiGene	2017-10-31	PHASE3
NCT03391466	COMPLETED	Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)	Kite, A Gilead Company	2018-01-25	PHASE3
NCT04385524	WITHDRAWN	Hepatitis B Virus	University of Louisville	2020-06-01
NCT04301336	COMPLETED	Vaso-occlusive Crisis; Sickle Cell Disease; Sickle Cell Anemia in Children	Beni-Suef University	2019-11-01	PHASE2; PHASE3
NCT04473027	Terminated	Melanoma\|Cancer	University Hospital Ghent\|Jessa Hospital\|University Hospital Antwerp\|Algemeen Ziekenhuis Maria Middelares\|GZA Ziekenhuizen Campus Sint-Augustinus\|AZ Sint-Jan AV\|AZ Nikolaas\|AZ Sint-Lucas Gent\|AZ Sint-Lucas Brugge\|General Hospital Groeninge\|OLV van Lourdes Hospital Waregem\|AZ Damiaan\|AZ Delta\|ASZ Aalst\|Belgian Red Cross	2020-09-01	--
NCT03559517	TERMINATED	Crohn's Disease	Shire	2018-08-29	PHASE3
NCT04219358	TERMINATED	Actinic Cheilitis	Hospital de Clinicas de Porto Alegre	2019-03-23	PHASE1
NCT03529708	UNKNOWN	Spinal Cord Compression; Cauda Equina Syndrome; Stereotactic Body Radiotherapy	Juravinski Cancer Center	2018-06-01
NCT03620435	UNKNOWN	Safety Issues	McGill University Health Centre/Research Institute of the McGill University Health Centre	2018-05-01	PHASE2
NCT04292730	COMPLETED	COVID-19	Gilead Sciences	2020-03-15	PHASE3
NCT04063904	TERMINATED	Second Trimester Abortion	Gynuity Health Projects	2019-10-16	PHASE4
NCT05277597	COMPLETED	Healthy Males	Poznan University of Physical Education	2020-02-10
NCT04097938	COMPLETED	Healthy	Lakefront Biotherapeutics NV	2019-09-18	PHASE1
NCT03083236	UNKNOWN	Speech and Language Therapy	Solent NHS Trust	2017-10
NCT03052517	TERMINATED	Asthma	Novartis Pharmaceuticals	2017-03-21	PHASE3
NCT02819973	COMPLETED	Sudden Cardiac Death; Heart Failure	Duke University	2016-07
NCT02983006	COMPLETED	Melanoma	NYU Langone Health	2016-10	PHASE1
NCT03589885	COMPLETED	Plaque Psoriasis	Novartis Pharmaceuticals	2018-12-19	PHASE3
NCT03192150	COMPLETED	Inflammation and Pain Associated With Cataract Surgery	Sun Pharmaceutical Industries Limited	2018-01-03	PHASE3
NCT03393806	TERMINATED	Asthma	GlaxoSmithKline	2018-04-18	PHASE2
NCT02908685	COMPLETED	Muscular Atrophy, Spinal	Hoffmann-La Roche	2016-10-19	PHASE2
NCT02915016	COMPLETED	HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)	2016-12-07	PHASE1; PHASE2
NCT04322825	COMPLETED	Spastic Cerebral Palsy	Hvidovre University Hospital	2017-06-01
NCT02278068	COMPLETED	Diabetes; Endocrine, Nutritional and Metabolic Diseases (E00-E89)	Metavention	2014-10
NCT03221634	WITHDRAWN	Multiple Myeloma	Merck Sharp & Dohme LLC	2017-08-01	PHASE2
NCT03586843	COMPLETED	Obesity	Janssen Research & Development, LLC	2018-06-29	PHASE1
NCT02840487	COMPLETED	Prevention of Zika Infection; Zika-Specific Immune Response	National Institute of Allergy and Infectious Diseases (NIAID)	2016-08-02	PHASE1
NCT03782987	COMPLETED	Healthy	Boehringer Ingelheim	2019-01-10	PHASE1
NCT03235349	COMPLETED	Hepatitis C Virus (HCV)	AbbVie	2017-09-29	PHASE3
NCT02241369	COMPLETED	Aerodigestive Precancerous Lesions and Malignancies	Inovio Pharmaceuticals	2014-05	PHASE1
NCT02882256	COMPLETED	Urinary Tract Infection; Head Injury; Laceration	George Washington University	2016-06
NCT02959476	COMPLETED	Pain, Postoperative	BioQ Pharma, Inc.	2017-03-13	PHASE3
NCT01752426	COMPLETED	Leukemia	M.D. Anderson Cancer Center	2012-12-17	PHASE1; PHASE2
NCT02699814	COMPLETED	Developmental Delay; Mental Health Disorder	University of California, Los Angeles	2016-03
NCT03015194	COMPLETED	Mitral Valve Failure	National Heart, Lung, and Blood Institute (NHLBI)	2017-06-20
NCT02873936	COMPLETED	Rheumatoid Arthritis	Gilead Sciences	2016-07-27	PHASE3
NCT02365363	COMPLETED	Diabetes Prevention; Obesity Prevention	University of Manitoba	2016-10
NCT02968121	TERMINATED	Schizophrenia	Otsuka Pharmaceutical Development & Commercialization, Inc.	2017-01	PHASE1
NCT03394508	COMPLETED	Rhinitis; Asthma; Allergy	Karolinska Institutet	2013-01	PHASE2; PHASE3
NCT02696512	UNKNOWN	Brain Injury	International Brain Research Foundation	2016-03	PHASE1; PHASE2
NCT02600598	COMPLETED	Actinic Keratosis	LEO Pharma	2016-07	PHASE1
NCT03376906	COMPLETED	Obesity; Endothelial Dysfunction	Federal University of Paraíba	2016-06-05
NCT02421367	COMPLETED	Dengue	U.S. Army Medical Research and Development Command	2015-08	PHASE1; PHASE2
NCT02801370	COMPLETED	Acute Otitis Externa; Swimmer's Ear	Otonomy, Inc.	2016-06	PHASE3
NCT02433652	COMPLETED	Dengue	National Institute of Allergy and Infectious Diseases (NIAID)	2015-09	PHASE1
NCT01061151	COMPLETED	HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)	2011-03-01	PHASE3
NCT02075255	COMPLETED	Asthma	AstraZeneca	2014-04-28	PHASE3
NCT02345174	COMPLETED	Cancer; Neoplasms	GlaxoSmithKline	2015-03-19	PHASE1
NCT01283516	COMPLETED	Tumors Characterized by Genetic Abnormalities of ALK	Novartis Pharmaceuticals	2011-01-24	PHASE1
NCT02401243	COMPLETED	Type 2 Diabetes Mellitus	Sanofi	2015-03	PHASE3
NCT01965652	COMPLETED	Opioid-induced Constipation	Shionogi	2013-09-24	PHASE3
NCT01935531	COMPLETED	Actinic Keratoses	University Hospital Regensburg	2013-06	PHASE4
NCT02322606	WITHDRAWN	Healthy Japanese Adult Male	Takeda	2014-11	PHASE1
NCT01850238	COMPLETED	Alzheimer Disease	Axon Neuroscience SE	2013-05	PHASE1
NCT02884310	COMPLETED	Intravenous Anesthetic Agent Overdose	Erasme University Hospital	2013-01	PHASE4
NCT01893580	TERMINATED	Lung Cancer; Non Small Cell Lung Cancer	Rigshospitalet, Denmark	2012-05
NCT01966965	UNKNOWN	PEDICULOSIS	Phytopharm Consulting Brazil	2014-07	PHASE3
NCT01879098	COMPLETED	Healthy	University of Florida	2013-08	PHASE1
NCT01599897	COMPLETED	Pulmonary Tuberculosis	Access to Advanced Health Institute (AAHI)	2012-08	PHASE1
NCT02028598	COMPLETED	Healthy	CTC Bio, Inc.	2014-01	PHASE1
NCT01681524	WITHDRAWN	Coronary Artery Disease	Lantheus Medical Imaging	2012-11	PHASE3
NCT00103285	COMPLETED	Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic Leukemia	Children's Oncology Group	2005-04-11	PHASE3
NCT01887535	COMPLETED	Healthy	Janssen Research & Development, LLC	2013-05	PHASE1
NCT01952548	COMPLETED	Safety and Tolerability	Kowa Research Institute, Inc.	2013-05	PHASE1
NCT01357317	UNKNOWN	Chronic Kidney Disease	Salem Veterans Affairs Medical Center	2011-06	PHASE3
NCT02055547	COMPLETED	Type 2 Diabetes Mellitus	Merck Sharp & Dohme LLC	2013-05-10	PHASE1
NCT02104895	COMPLETED	Breast Cancer	Azienda Ospedaliero-Universitaria Careggi	2005-03	PHASE3
NCT00829699	COMPLETED	Type 2 Diabetes	University of Maryland, Baltimore	2009-07	EARLY_PHASE1
NCT01807299	COMPLETED	Attention Deficit Hyperactivity Disorder	Federal University of São Paulo	2011-05
NCT01900184	COMPLETED	Essential Hypertension	Quantum Genomics SA	2012-12	PHASE1
NCT00994318	COMPLETED	Iron Deficiency Anaemia; Chronic Kidney Disease	Vifor Pharma	2009-12	PHASE3
NCT01435668	COMPLETED	Alcohol Abuse, Episodic Drinking Behavior	Rennes University Hospital	2011-09
NCT01257984	COMPLETED	Contraception	Bayer	2010-12	PHASE3
NCT01271933	COMPLETED	Fibromyalgia	Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	2011-03	PHASE3
NCT02155036	COMPLETED	Chronic Kidney Disease	King's College Hospital NHS Trust	2011-06	PHASE1; PHASE2
NCT01438749	COMPLETED	Healthy Volunteer	Hoffmann-La Roche	2011-10	PHASE1
NCT01257204	COMPLETED	Hepatitis C Virus	Bristol-Myers Squibb	2010-12	PHASE2
NCT00888108	COMPLETED	Solid Tumor	Abbott	2009-07	PHASE1
NCT01057693	COMPLETED	Diabetic Neuropathy, Painful	Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	2010-03-31	PHASE3
NCT01229605	WITHDRAWN	Breast Cancer	Tufts Medical Center	2010-10	PHASE2
NCT01314885	COMPLETED	Chronic Obstructive Pulmonary Disease (COPD)	Pfizer	2011-01	PHASE1
NCT01308541	COMPLETED	Monitored Anesthesia Care	Eisai Inc.	2011-01	PHASE1
NCT01353404	COMPLETED	Hyperlipidemia	Samyang Biopharmaceuticals Corporation	2011-06	PHASE1
NCT00877474	COMPLETED	ADVANCED SOLID TUMORS	PharmaMar	2009-03	PHASE1
NCT00089583	COMPLETED	Infection, Human Immunodeficiency Virus I	ViiV Healthcare	2004-07	PHASE2
NCT00952887	COMPLETED	Muscular Atrophy	Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA	2009-08	PHASE1
NCT00941252	COMPLETED	Cervical Intraepithelial Neoplasia	Medical University of Vienna	2009-07	PHASE2; PHASE3
NCT01213849	COMPLETED	Asthma	GlaxoSmithKline	2010-10-04	PHASE1
NCT00992459	COMPLETED	Urea Cycle Disorders	Amgen	2009-10	PHASE3
NCT00481767	COMPLETED	Human Papillomavirus (HPV) Infection	GlaxoSmithKline	2007-10-01	PHASE3
NCT00328692	COMPLETED	Heart Failure, Congestive	NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)	2006-08	PHASE3
NCT01362244	Completed	Nasal Polyps	GlaxoSmithKline	2009-05-12	Phase 2
NCT00513578	UNKNOWN	Myelodysplastic Syndromes	The Vaccine Company	2007-01	PHASE2
NCT00664716	COMPLETED	Rheumatoid Arthritis	Biogen	2007-07	PHASE2
NCT00280566	COMPLETED	Bipolar Mania; Bipolar Disorder	Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	2005-12	PHASE3
NCT00403416	COMPLETED	Kidney Transplantation	Novartis Pharmaceuticals	2006-10	PHASE1; PHASE2
NCT00511433	COMPLETED	Contraception	Organon and Co	2006-10	PHASE3
NCT00454987	COMPLETED	Haemophilus Influenzae Type b; Neisseria Meningitidis; Neisseria Meningitidis-Haemophilus Influenzae Type b Vaccine	GlaxoSmithKline	2007-05-16	PHASE4
NCT00134264	TERMINATED	Coronary Disease; Diabetes Mellitus	Pfizer	2004-07	PHASE3
NCT00474799	Completed	Healthy	Javelin Pharmaceuticals	2007-01	Phase 1
NCT00324129	COMPLETED	Leukemia; Myelodysplastic Syndromes	Mirati Therapeutics Inc.	2005-02	PHASE1
NCT01687556	COMPLETED	Acne Vulgaris	Seoul National University Hospital	2005-07
NCT00068484	COMPLETED	Unspecified Adult Solid Tumor, Protocol Specific	National Cancer Institute (NCI)	2003-07	PHASE1
NCT01600820	COMPLETED	Hypercholesterolemia	Danone Spain	2005-02
NCT00042978	COMPLETED	Extensive Stage Small Cell Lung Cancer; Recurrent Small Cell Lung Cancer	National Cancer Institute (NCI)	2003-04	PHASE2
NCT00888680	WITHDRAWN	Migraine	Boston Scientific Corporation		PHASE2
NCT00225615	COMPLETED	Phenylketonurias	BioMarin Pharmaceutical	2005-11	PHASE3
NCT00300404	COMPLETED	Schizophrenia; Major Depression	Zentrum für Integrative Psychiatrie	2002-01	PHASE3

(data from https://clinicaltrials.gov, updated on 2026-09-04)

Check the MNS (3,4-Methylenedioxy-β-nitrostyrene) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

MNS functions as a small-molecule inhibitor that binds spleen tyrosine kinase (Syk), Src, and p97, thereby blocking downstream tyrosine phosphorylation and key biochemical signal transduction pathways. This biochemical inhibition suppresses downstream cellular proliferation and survival mechanisms, which inhibits tumor expansion and pathologic cellular activation in clinical conditions such as melanoma and inflammatory diseases.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).