CAS No. 163655-37-6

Batch: Purity:99.31
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MAZ51 Chemical Structure
Chemical Structure
Check the MAZ51 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[[4-(dimethylamino)naphthalen-1-yl]methylidene]-1H-indol-2-one
CAS Number 163655-37-6
Molecular Formula

C21H18N2O
Molecular Weight (MW) 314.38
SMILES CN(C)C1=CC=C(C2=CC=CC=C21)C=C3C4=CC=CC=C4NC3=O
InChIKey VFCXONOPGCDDBQ-UHFFFAOYSA-N

Ordering Information

Biological Activity

MAZ51 is a small-molecule inhibitor targeting vascular endothelial growth factor receptor-3 (VEGFR-3/Flt-4) tyrosine kinase. Blockade of VEGFR-3 signaling impacts key downstream cascades including Akt/GSK3β phosphorylation and RhoA activation, leading to cell rounding and G2/M cell cycle arrest. Through these mechanism-driven pathway alterations, MAZ51 suppresses cellular proliferation and triggers apoptosis in multiple tumor cell lines. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (200.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.