CAS No. 519-02-8

Batch: Purity:99.72
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(+)-Matrine Chemical Structure
Chemical Structure
Check the (+)-Matrine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
CAS Number 519-02-8
Molecular Formula

C15H24N2O
Molecular Weight (MW) 248.36
SMILES C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1
InChIKey ZSBXGIUJOOQZMP-JLNYLFASSA-N

Ordering Information

Biological Activity

(+)-Matrine is a natural lupin alkaloid derived from Sophora species that functions as a kappa opioid receptor agonist and possesses multi-target anti-cancer activity. It inhibits cancer cell proliferation, arrests the cell cycle, and induces apoptosis by modulating signaling pathways such as PI3K/AKT, NF-kB, and MAPK. Additionally, (+)-Matrine demonstrates protective effects against inflammation and fibrosis across various cell models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (201.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 50 mg/mL
Ethanol 50 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.