CAS No. 1227962-62-0

Batch: Purity:99.66
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Marinopyrrole A (Maritoclax) Chemical Structure
Chemical Structure
Check the Marinopyrrole A (Maritoclax) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1227962-62-0
Molecular Formula

C22H12Cl4N2O4
Molecular Weight (MW) 510.15
SMILES C1=CC=C(C(=C1)C(=O)C2=CC(=C(N2C3=C(NC(=C3Cl)Cl)C(=O)C4=CC=CC=C4O)Cl)Cl)O

Ordering Information

Biological Activity

Marinopyrrole A (Maritoclax) is a selective Mcl-1 antagonist that disrupts the Bim/Mcl-1 interaction with an IC50 of 10.1 μM. It selectively binds to Mcl-1 over Bcl-xL and targets Mcl-1 for proteasomal degradation. By disrupting Mcl-1 function, Maritoclax downregulates anti-apoptotic signaling pathways, triggers mitochondrial membrane permeabilization, and induces apoptosis in hematological cancer cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (196.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 59 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.