Marimastat (BB-2516): Selectivity & Specificity

Marimastat (BB-2516) is a potent inhibitor of MMP-9 (3 nM), MMP-1 (5 nM), MMP-2 (6 nM), MMP-14 (9 nM), MMP-7 (13 nM), D. typus crude venom (34.2 nM), D. russelii venom (Madhya Pradesh: MP) (1508 nM), D. russelii venom (Rajasthan: RJ) (1667 nM), D. russelii venom (Andhra Pradesh: AP) (1957 nM), D. russelii venom (Karnataka: KA) (1977 nM), D. russelii venom (Goa: GA) (2330 nM), MMP, SVMP. Marimastat (BB-2516) exhibits the greatest inhibitory potency toward MMP-9 (IC50 = 3 nM).