Maraviroc (UK-427857) is a potent, allosteric CCR5 antagonist. It affects CCL5/CCR5 and PI3K/AKT signaling pathways by binding to the receptor's transmembrane domain and stabilizing its inactive conformation, effectively inhibiting HIV-1 entry, macrophage polarization, and inflammation.
Maraviroc (UK-427857) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Maraviroc (UK-427857) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.