CAS No. 476-28-8

Batch: Purity:99.86
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Lycorine Chemical Structure
Chemical Structure
Check the Lycorine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol
CAS Number 476-28-8
Molecular Formula

C16H17NO4
Molecular Weight (MW) 287.31
SMILES C1CN2CC3=CC4=C(C=C3C5C2C1=CC(C5O)O)OCO4
InChIKey XGVJWXAYKUHDOO-DANNLKNASA-N

Biological Activity

Lycorine is a natural crystalline alkaloid isolated from Amaryllidaceae species that functions as a weak inhibitor of acetylcholinesterase (AChE) and ascorbic acid biosynthesis. It interferes with key cellular processes to suppress cell proliferation and induce apoptosis in various cancer cell models. At the molecular level, lycorine modulates oncogenic signaling pathways to trigger cell cycle arrest, inhibit tumor growth, and reduce metastatic potential. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 40 mg/mL (139.22 mM) ; Warmed with 60°C water bath ; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Nat. Prod. Rep. 2010;27(1):9-10.

[2] Liu Y, et al. Cancer Lett. 2009;274(1):47-53.

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Note: Technical data last updated: Sep 1, 2026.