CAS No. 396129-53-6

Batch: Purity:99.93
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LY364947 Chemical Structure
Chemical Structure
Check the LY364947 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-(5-pyridin-2-yl-1H-pyrazol-4-yl)quinoline
CAS Number 396129-53-6
Molecular Formula

C17H12N4
Molecular Weight (MW) 272.3
SMILES C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4
InChIKey IBCXZJCWDGCXQT-UHFFFAOYSA-N

Ordering Information

Biological Activity

LY364947 is a potent, ATP-competitive inhibitor of TGFβR-I with an IC50 ofin a cell-free assay, demonstrating 7-fold selectivity over TGFβR-II. By targeting the TGFβR-I kinase domain, LY364947 blocks downstream Smad2 and Smad3 phosphorylation within the canonical TGF-beta pathway. This functional inhibition effectively suppresses epithelial-mesenchymal transition, cellular migration, and tumor invasion. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 4 mg/mL (14.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.