CAS No. 1421438-81-4

Batch: Purity:98.88
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Crenigacestat (LY3039478) Chemical Structure
Chemical Structure
Check the Crenigacestat (LY3039478) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4,4,4-trifluoro-N-[(2S)-1-[[(7S)-5-(2-hydroxyethyl)-6-oxo-7H-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-oxopropan-2-yl]butanamide
CAS Number 1421438-81-4
Molecular Formula

C22H23F3N4O4
Molecular Weight (MW) 464.44
SMILES CC(C(=O)NC1C2=CC=CC=C2C3=C(N=CC=C3)N(C1=O)CCO)NC(=O)CCC(F)(F)F
InChIKey YCBAQKQAINQRFW-UGSOOPFHSA-N

Ordering Information

Biological Activity

Crenigacestat (LY3039478) is a potent oral inhibitor of Notch signaling and gamma-secretase. By blocking gamma-secretase-mediated proteolytic cleavage of Notch receptors, it prevents the release of the Notch intracellular domain and suppresses downstream transcription of target genes. Inhibition of this cascade impairs cell proliferation and induces cell cycle arrest and apoptosis in Notch-dependent cell lines. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 93 mg/mL (200.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 93 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.