CAS No. 1234015-54-3
Batch:
Purity:99.88
Chemical Structure
Check the
Prexasertib (LY2606368) Dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile;dihydrochloride | |
|---|---|---|
| CAS Number | 1234015-54-3 | |
| Molecular Formula |
C18H19N7O2.2HCl |
|
| Molecular Weight (MW) | 438.31 | |
| SMILES | COC1=C(C(=CC=C1)OCCCN)C2=CC(=NN2)NC3=NC=C(N=C3)C#N.Cl.Cl | |
| InChIKey | KMEIPKXRCJTZBZ-UHFFFAOYSA-N |
Prexasertib Dihydrochloride (LY2606368 Dihydrochloride) is an ATP-competitive inhibitor of CHK1, CHK2, and RSK. By blocking CHK1 and CHK2 signaling, it abrogates DNA damage checkpoints, leading to persistent double-strand DNA breaks, impaired DNA repair, and premature mitotic entry. These molecular disruptions ultimately trigger mitotic catastrophe and apoptotic cell death in cancer cells. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
17 mg/mL
(38.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
14 mg/mL
(31.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
9 mg/mL
(20.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
30 mg/mL
(68.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
2 mg/mL
(4.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Prexasertib (LY2606368) Dihydrochloride Clinical Trials
- Prexasertib (LY2606368) Dihydrochloride Solubility in DMSO
- Prexasertib (LY2606368) Dihydrochloride Stock Solution
- Prexasertib (LY2606368) Dihydrochloride Storage
- Prexasertib (LY2606368) Dihydrochloride Stability
- Prexasertib (LY2606368) Dihydrochloride Molecular Weight
- Prexasertib (LY2606368) Dihydrochloride SMILES
- Prexasertib (LY2606368) Dihydrochloride Chemical Structure (2D and 3D)
- Prexasertib (LY2606368) Dihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.