CAS No. 1082949-67-4

Batch: Purity:99.02
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LY2584702 Chemical Structure
Chemical Structure
Check the LY2584702 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo[5,4-d]pyrimidine
CAS Number 1082949-67-4
Molecular Formula

C21H19F4N7
Molecular Weight (MW) 445.42
SMILES CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F
InChIKey FYXRSVDHGLUMHB-UHFFFAOYSA-N

Biological Activity

LY2584702 is a selective, ATP-competitive p70S6K inhibitor with an IC50 of. By directly suppressing p70S6K enzymatic activity, it blocks the phosphorylation of downstream ribosomal protein S6 within the mTOR signaling pathway. This disruption impairs protein translation, cellular proliferation, and cell survival, thereby attenuating tumor growth driven by dysregulated kinase pathway activation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 4.44 mg/mL (9.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Magnuson B, et al. Biochem J. 2012;441(1):1-21.

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Note: Technical data last updated: Sep 1, 2026.