CAS No. 1082949-68-5

Batch: Purity:99.57
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LY2584702 Tosylate Chemical Structure
Chemical Structure
Check the LY2584702 Tosylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo[5,4-d]pyrimidine;4-methylbenzenesulfonic acid
CAS Number 1082949-68-5
Molecular Formula

C28H27F4N7O3S
Molecular Weight (MW) 617.62
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F
InChIKey HDYUXDNMHBQKAU-UHFFFAOYSA-N

Biological Activity

LY2584702 Tosylate is a selective, ATP-competitive inhibitor of p70S6K. Targeted inhibition of p70S6K disrupts signaling through the canonical AKT/mTOR pathway by blocking the downstream phosphorylation of ribosomal protein S6. This impairment suppresses translation initiation, ribosomal biogenesis, and protein synthesis, resulting in reduced cell proliferation and the inhibition of cell growth and survival in p70S6K-dependent tumor models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 7 mg/mL (11.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Magnuson B, et al. Biochem J. 2012;441(1):1-21.

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Note: Technical data last updated: Sep 1, 2026.