CAS No. 2166616-75-5
Batch:
Purity:99.82
Chemical Structure
Check the
LY-3381916
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-fluoro-N-[(1R)-1-[1-(oxane-4-carbonyl)-2,3-dihydroindol-5-yl]ethyl]benzamide | |
|---|---|---|
| CAS Number | 2166616-75-5 | |
| Molecular Formula |
C23H25FN2O3
|
|
| Molecular Weight (MW) | 396.45 | |
| SMILES | CC(C1=CC2=C(C=C1)N(CC2)C(=O)C3CCOCC3)NC(=O)C4=CC=C(C=C4)F | |
| InChIKey | NUBWFWVVKLRSHS-OAHLLOKOSA-N |
LY-3381916 is a potent, selective, and brain-penetrant indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. By targeting IDO1, it blocks the catalytic conversion of tryptophan to kynurenine, thereby relieving immunosuppression in the tumor microenvironment and restoring immune surveillance. Publicly reported preclinical evaluations demonstrate that LY-3381916 effectively crosses the blood-brain barrier and exhibits marked anti-tumor activity in targeted cancer models. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(199.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.