CAS No. 875787-07-8

Batch: Purity:99.48
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LXR-623 (WAY-252623) Chemical Structure
Chemical Structure
Check the LXR-623 (WAY-252623) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)indazole
CAS Number 875787-07-8
Molecular Formula

C21H12ClF5N2
Molecular Weight (MW) 422.78
SMILES C1=CC2=C(N(N=C2C(=C1)C(F)(F)F)CC3=C(C=C(C=C3)F)Cl)C4=CC=C(C=C4)F
InChIKey KYWWJENKIMRJBI-UHFFFAOYSA-N

Ordering Information

Biological Activity

LXR-623 (WAY-252623) is an orally bioavailable agonist of liver X receptor-α (LXR-α, and liver X receptor-β (LXR-β,. Activation of LXRs by LXR-623 upregulates the expression of ATP-binding cassette transporters ABCA1 and ABCG1, promoting reverse cholesterol transport and cellular lipid efflux. Concurrently, it suppresses pro-inflammatory gene expression, effectively reducing atherosclerotic lesion progression in dyslipidemic animal models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (198.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 84 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.