CAS No. 117946-91-5
Batch:
Purity:99.47
Chemical Structure
Check the
Luzindole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-(2-benzyl-1H-indol-3-yl)ethyl]acetamide | |
|---|---|---|
| CAS Number | 117946-91-5 | |
| Molecular Formula |
C19H20N2O |
|
| Molecular Weight (MW) | 292.37 | |
| SMILES | CC(=O)NCCC1=C(CC2=CC=CC=C2)[NH]C3=CC=CC=C13 | |
| InChIKey | WVVXBPKOIZGVNS-UHFFFAOYSA-N |
Luzindole is a selective melatonin receptor antagonist that preferentially targets the MT2 receptor over the MT1 receptor. Blockade of these receptors inhibits downstream G protein-coupled signaling pathways, modulating intracellular cyclic AMP levels and regulating neuronal excitability and circadian rhythms. Consequently, luzindole alters biological processes including sleep-wake cycle regulation, vascular responses, and neural plasticity in preclinical research models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(198.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 58 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.