CAS No. 76684-89-4
| IUPAC Name | (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid | |
|---|---|---|
| CAS Number | 76684-89-4 | |
| Molecular Formula |
C15H26 N2 O5 |
|
| Molecular Weight (MW) | 314.38 | |
| SMILES | CC(C)CCNC(=O)C(CC(C)C)NC(=O)C1C(O1)C(=O)O | |
| InChIKey | SCMSYZJDIQPSDI-SRVKXCTJSA-N |
Loxistatin Acid (E-64C) is an irreversible, membrane-permeant cysteine protease inhibitor targeting cysteine cathepsins, including cathepsin L and cathepsin B. By covalently modifying the active site cysteine residue of these enzymes, it suppresses lysosomal protein degradation and extracellular matrix turnover. Furthermore, inhibition of host cysteine proteases such as cathepsin L blocks endosomal cleavage of viral envelope proteins, thereby attenuating viral entry processes including SARS-CoV-2 entry. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(197.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 62 mg/mL |
| Water | 2 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- Loxistatin Acid (E-64C) Solubility in DMSO
- Loxistatin Acid (E-64C) Stock Solution
- Loxistatin Acid (E-64C) Storage
- Loxistatin Acid (E-64C) Stability
- Loxistatin Acid (E-64C) Molecular Weight
- Loxistatin Acid (E-64C) SMILES
- Loxistatin Acid (E-64C) Chemical Structure (2D and 3D)
- Loxistatin Acid (E-64C) SDS｜MSDS