CAS No. 27833-64-3
| IUPAC Name | butanedioic acid;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine | |
|---|---|---|
| CAS Number | 27833-64-3 | |
| Molecular Formula |
C18H18ClN3O.C4H6O4 |
|
| Molecular Weight (MW) | 445.9 | |
| SMILES | CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl.C(CC(=O)O)C(=O)O | |
| InChIKey | YQZBAXDVDZTKEQ-UHFFFAOYSA-N |
Loxapine Succinate is a dibenzoxazepine antipsychotic agent that acts as a dopamine D2 receptor (D2DR) and D4 receptor (D4DR) inhibitor and serotonergic receptor antagonist. By blocking central dopamine and serotonin receptors, it modulates neurotransmitter signaling pathways involved in dopaminergic and serotonergic neurotransmission. This receptor antagonism leads to downstream inhibition of dopamine-mediated signaling and suppression of hyperactive behavioral phenotypes in preclinical models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(199.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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