CAS No. 124750-99-8
Batch:
Purity:99.96
Chemical Structure
Check the
Losartan Potassium (DuP 753)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | potassium [2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol | |
|---|---|---|
| CAS Number | 124750-99-8 | |
| Molecular Formula |
C22H23ClKN6O |
|
| Molecular Weight (MW) | 462.01 | |
| SMILES | CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+] | |
| InChIKey | OXCMYAYHXIHQOA-UHFFFAOYSA-N |
Losartan Potassium is an angiotensin II receptor antagonist that competes with angiotensin II for binding to AT1 receptors with an IC50 of 20 nM. By blocking AT1 receptor activation, it inhibits downstream signal transduction pathways involved in vascular smooth muscle contraction and cellular proliferation. This inhibition attenuates renin-angiotensin-aldosterone system-mediated signaling, thereby modulating vascular tone and cellular responses. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 92 mg/mL |
| Ethanol | 92 mg/mL |
| DMSO |
92 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 92 mg/mL |
| Ethanol | 92 mg/mL |
| DMSO |
92 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 92 mg/mL |
| Ethanol | 92 mg/mL |
| DMSO |
92 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 92 mg/mL |
| Ethanol | 92 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Losartan Potassium (DuP 753) Clinical Trials
- Losartan Potassium (DuP 753) Solubility in DMSO
- Losartan Potassium (DuP 753) Stock Solution
- Losartan Potassium (DuP 753) Storage
- Losartan Potassium (DuP 753) Stability
- Losartan Potassium (DuP 753) Molecular Weight
- Losartan Potassium (DuP 753) SMILES
- Losartan Potassium (DuP 753) Chemical Structure (2D and 3D)
- Losartan Potassium (DuP 753) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.