CAS No. 124750-92-1

Batch: Purity:99.41
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Losartan Carboxylic Acid (EXP-3174) Chemical Structure
Chemical Structure
Check the Losartan Carboxylic Acid (EXP-3174) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 124750-92-1
Molecular Formula

C22H21ClN6O2
Molecular Weight (MW) 436.89
SMILES CCCCC1=NC(=C([N]1CC2=CC=C(C=C2)C3=CC=CC=C3C4=N[NH]N=N4)C(O)=O)Cl

Ordering Information

Biological Activity

Losartan Carboxylic Acid (EXP-3174) is a non-peptide angiotensin II receptor type 1 (AT1) antagonist and the active metabolite of losartan. It potently inhibits the specific binding of radiolabeled angiotensin II to vascular smooth muscle cells with an IC50 of. By blocking AT1 receptors, it attenuates angiotensin II-mediated vasoconstriction and intracellular signaling pathways involved in cardiovascular regulation. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 87 mg/mL (199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 87 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.