CAS No. 18524-94-2
Batch:
Purity:99.94
Chemical Structure
Check the
Loganin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | methyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate | |
|---|---|---|
| CAS Number | 18524-94-2 | |
| Molecular Formula |
C17H26O10 |
|
| Molecular Weight (MW) | 390.38 | |
| SMILES | CC1C(CC2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O | |
| InChIKey | AMBQHHVBBHTQBF-UOUCRYGSSA-N |
Loganin is an iridoid glycoside that acts as an inhibitor of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site APP cleaving enzyme 1 (BACE1). By regulating cholinergic neurotransmission and amyloid-beta precursor processing, loganin suppresses oxidative stress and attenuates NF-kB-mediated inflammatory signaling pathways, resulting in enhanced neuronal cell survival and broad neuroprotective activity in preclinical disease models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.