CAS No. 1418033-25-6
Batch:
Purity:99.94
Chemical Structure
Check the
LMK-235
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[6-(hydroxyamino)-6-oxohexoxy]-3,5-dimethylbenzamide | |
|---|---|---|
| CAS Number | 1418033-25-6 | |
| Molecular Formula |
C15H22N2O4 |
|
| Molecular Weight (MW) | 294.35 | |
| SMILES | CC1=CC(=CC(=C1)C(=O)NOCCCCCC(=O)NO)C | |
| InChIKey | VRYZCEONIWEUAV-UHFFFAOYSA-N |
LMK-235 is a selective histone deacetylase inhibitor targeting HDAC4 (IC50 of and HDAC5 (IC50 of. By inhibiting class IIa HDAC activity, LMK-235 alters histone acetylation levels and modulates chromatin structure, leading to transcriptional regulation. This compound suppresses cell proliferation and induces apoptosis in cancer cellular models, serving as a useful tool for probing HDAC isoform function. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(200.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 59 mg/mL |
| Water | Insoluble |
| DMSO |
7 mg/mL
(23.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
59 mg/mL
(200.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 59 mg/mL |
| Water | Insoluble |
| DMSO |
58 mg/mL
(197.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 58 mg/mL |
| Water | Insoluble |
| DMSO |
6 mg/mL
(20.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.