CAS No. 83915-83-7

Batch: Purity:99.99
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Lisinopril dihydrate Chemical Structure
Chemical Structure
Check the Lisinopril dihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;dihydrate
CAS Number 83915-83-7
Molecular Formula

C21H35N3O7
Molecular Weight (MW) 441.52
SMILES C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
InChIKey CZRQXSDBMCMPNJ-ZUIPZQNBSA-N

Ordering Information

Biological Activity

Lisinopril dihydrate is a potent inhibitor of angiotensin-converting enzyme (ACE) that targets the renin-angiotensin-aldosterone system (RAAS). By inhibiting ACE, it prevents the enzymatic conversion of angiotensin I to angiotensin II, thereby blocking angiotensin II-mediated signal transduction. This inhibition downregulates downstream vascular smooth muscle contraction, suppresses aldosterone secretion, and attenuates inflammatory pathways involved in vascular remodeling. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 88 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.