CAS No. 578-86-9
Batch:
Purity:98.7557
Chemical Structure
Check the
Liquiritigenin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one | |
|---|---|---|
| CAS Number | 578-86-9 | |
| Molecular Formula |
C15H12O4 |
|
| Molecular Weight (MW) | 256.25 | |
| SMILES | C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O | |
| InChIKey | FURUXTVZLHCCNA-AWEZNQCLSA-N |
Liquiritigenin is a selective estrogen receptor β (ERβ) agonist that selectively binds to ERβ. It drives transcription via ERβ-responsive regulatory elements and activates native target genes downstream of ERβ without stimulating ERα activity. Through ERβ-mediated signal transduction, liquiritigenin modulates gene expression pathways involved in cellular differentiation and transcriptional regulation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(199.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 51 mg/mL |
| Water | Insoluble |
| DMSO |
51 mg/mL
(199.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.