Target Selectivity of Linsitinib (OSI-906)
| Key Target | IC50 | Description | Reference |
|---|---|---|---|
| IGF-1R | 35 nM | Half maximal inhibitory concentration (IC50) determination for tyrosine kinase inhibition | PMC6292546 |
| Insulin Receptor | 75 nM | Half maximal inhibitory concentration (IC50) determination for tyrosine kinase inhibition | PMC6292546 |
| ABCG2 | 1 µM | Concentrations for reversal activity on MDR | PMC11182121 |
| ABCC10 | 1 µM | Concentrations for reversal activity on MDR | PMC11182121 |
Check the
Linsitinib (OSI-906)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
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- Linsitinib (OSI-906) Mechanism of Action: IGF-1R Inhibition in Orbital Fibroblast Research
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- Linsitinib (OSI-906) Combination Database
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- Linsitinib (OSI-906) IC50 for Cell-based and Cell-free Assays
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- Linsitinib (OSI-906) SDS｜MSDS