Linsitinib (OSI-906) is a potent small-molecule dual IGF-1R/IR kinase inhibitor. It blocks PI3K/Akt and MAPK/ERK signaling by suppressing receptor phosphorylation, effectively inhibiting tumor cell proliferation, migration, and inducing apoptosis.
Linsitinib (OSI-906) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Linsitinib (OSI-906) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.