Cell-free Assays (IC50/Ki) for Linsitinib (OSI-906)
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| IGF-1R | 35 nmol/L | Tyrosine kinase IC₅₀ assay | PMC6292546 |
| Insulin Receptor | 75 nmol/L | Tyrosine kinase IC₅₀ assay | PMC6292546 |
Cell-based Assay (IC50) for Linsitinib (OSI-906)
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| OHS | 25 nM | WST-1 assay | Download PDF |
| OHS | 37 nM | WST-1 assay | Download PDF |
| SAOS2 | 92 nM | WST-1 assay | Download PDF |
| SAOS2 | 57 nM | WST-1 assay | Download PDF |
| KPD | 90 nM | WST-1 assay | Download PDF |
| KPD | 23 nM | WST-1 assay | Download PDF |
| ECA109 | 5 uM | CCK-8 assay | Download PDF |
| KYSE150 | 20 uM | CCK-8 assay | Download PDF |
| WT-m1 (300) | 1.2 μM | Cell viability assay | PMC7649750 |
| WT-m2 (5770) | 1.1 μM | Cell viability assay | PMC7649750 |
| Mut-m1 (3417) | 0.3 μM | Cell viability assay | PMC7649750 |
| Mut-m2 (3418) | 0.4 μM | Cell viability assay | PMC7649750 |
| WT-h1 (A375) | 1.3 μM | Cell viability assay | PMC7649750 |
| WT-h2 (RPMI-7951) | 1.4 μM | Cell viability assay | PMC7649750 |
| Mut-h1 (SKMEL-24) | 0.5 μM | Cell viability assay | PMC7649750 |
| Mut-h2 (WM278) | 0.6 μM | Cell viability assay | PMC7649750 |
| H295R | 0.15 μM | Measurement of total DNA content assay | Download PDF |
| HAC15 | 0.029 μM | Measurement of total DNA content assay | Download PDF |
Check the
Linsitinib (OSI-906)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Jump to
- Linsitinib (OSI-906) Mechanism of Action: IGF-1R Inhibition in Orbital Fibroblast Research
- Linsitinib (OSI-906) Clinical Trials
- Linsitinib (OSI-906) Working Concentration | Cell Culture | Treatment
- Linsitinib (OSI-906) Solubility in DMSO
- Linsitinib (OSI-906) Stock Solution
- Linsitinib (OSI-906) Storage
- Linsitinib (OSI-906) Stability
- Linsitinib (OSI-906) Combination Database
- Linsitinib (OSI-906) Molecular Weight
- Linsitinib (OSI-906) SMILES
- Linsitinib (OSI-906) CAS Number
- Linsitinib (OSI-906) Chemical Structure (2D and 3D)
- Linsitinib (OSI-906) Sigma (AMBH2D6FB336)? Try a better option.
- Linsitinib (OSI-906) MedChemExpress (HY-10191)? Try a better option.
- Linsitinib (OSI-906) Cayman (17708)? Try a better option.
- Linsitinib (OSI-906) Abcam (ab273391)? Try a better option.
- Linsitinib (OSI-906) APExBIO (A8334)? Try a better option.
- Linsitinib (OSI-906) SDS｜MSDS