CAS No. 76494-51-4
Batch:
Purity:99.65
Chemical Structure
Check the
Ligustrazine hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 76494-51-4 | |
|---|---|---|
| Molecular Formula |
C8H12N2.HCl |
|
| Molecular Weight (MW) | 172.66 | |
| SMILES | CC1=C(N=C(C(=N1)C)C)C.Cl |
Ligustrazine hydrochloride is a natural pyrazine alkaloid with broad anti-inflammatory, antioxidant, antiplatelet, and anti-apoptotic activities. Ligustrazine attenuates NF-kB signaling pathway activation and decreases reactive oxygen species generation, suppressing downstream pro-inflammatory cytokine expression. Additionally, it inhibits caspase-3-dependent apoptosis pathways and platelet aggregation, thereby mitigating cellular damage and vascular oxidative stress in preclinical models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
34 mg/mL
(196.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Ligustrazine hydrochloride Solubility in DMSO
- Ligustrazine hydrochloride Stock Solution
- Ligustrazine hydrochloride Storage
- Ligustrazine hydrochloride Stability
- Ligustrazine hydrochloride Molecular Weight
- Ligustrazine hydrochloride SMILES
- Ligustrazine hydrochloride Chemical Structure (2D and 3D)
- Ligustrazine hydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.