CAS No. 170632-47-0

Batch: Purity:99.94
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YC-1 (Lificiguat) Chemical Structure
Chemical Structure
Check the YC-1 (Lificiguat) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [5-(1-benzylindazol-3-yl)furan-2-yl]methanol
CAS Number 170632-47-0
Molecular Formula

C19H16N2O2
Molecular Weight (MW) 304.34
SMILES C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO
InChIKey OQQVFCKUDYMWGV-UHFFFAOYSA-N

Biological Activity

YC-1 (Lificiguat) is a nitric oxide (NO)-independent activator of soluble guanylyl cyclase (sGC) and an inhibitor of hypoxia-inducible factor-1α (HIF-1α). Activation of sGC increases intracellular cyclic GMP (cGMP) accumulation, suppressing platelet aggregation and vascular smooth muscle contraction. Additionally, YC-1 downregulates HIF-1α protein levels under hypoxic conditions, blocking HIF-1-mediated transcriptional activity and inhibiting tumor angiogenesis and cell proliferation. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 61 mg/mL (200.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 31 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Ko FN, et al. Blood. 1994;84(12):4226-33.

[2] Yeo EJ, et al. J Natl Cancer Inst. 2003;95(7):516-25.

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Note: Technical data last updated: Sep 1, 2026.