CAS No. 144506-15-0
Batch:
Purity:99.95
Chemical Structure
Check the
Licochalcone D
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one | |
|---|---|---|
| CAS Number | 144506-15-0 | |
| Molecular Formula |
C21H22O5 |
|
| Molecular Weight (MW) | 354.40 | |
| InChIKey | RETRVWFVEFCGOK-RMKNXTFCSA-N |
Licochalcone D is a natural flavonoid isolated from Glycyrrhiza inflata that functions as an inhibitor of JAK2, EGFR, and Met signaling pathways. It attenuates lipopolysaccharide-induced p65 NF-kB phosphorylation and inhibits tyrosine kinase activity. These targeted molecular interactions promote caspase activation, poly (ADP-ribose) polymerase (PARP) cleavage, and reactive oxygen species-dependent induction of apoptosis across various cancer cell lines. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(282.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.