CAS No. 141505-33-1

Batch: Purity:99.95
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Levosimendan Chemical Structure
Chemical Structure
Check the Levosimendan product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[4-[(4R)-4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile
CAS Number 141505-33-1
Molecular Formula

C14H12N6O
Molecular Weight (MW) 280.28
SMILES CC1CC(=O)NN=C1C2=CC=C(C=C2)NN=C(C#N)C#N
InChIKey WHXMKTBCFHIYNQ-SECBINFHSA-N

Ordering Information

Biological Activity

Levosimendan is a calcium sensitizer that selectively binds to cardiac troponin C (cTnC) in a calcium-dependent manner. By stabilizing the calcium-bound conformation of cTnC without increasing intracellular calcium concentration, levosimendan enhances myocardial contractility and cardiac muscle sensitivity to calcium. Additionally, levosimendan activates ATP-sensitive potassium channels, promoting vasodilation and cardioprotection in cardiac tissue. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 56 mg/mL (199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.