CAS No. 116209-55-3
| CAS Number | 116209-55-3 | |
|---|---|---|
| Molecular Formula |
C18H29NO3.HCl |
|
| Molecular Weight (MW) | 343.89 | |
| SMILES | CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O.Cl |
Levobetaxolol HCl is a selective β-adrenergic receptor antagonist with high affinity for human β1-adrenergic receptor (Ki = 0.76 nM) and human β2-adrenergic receptor (Ki = 32.6 nM). By blocking β-adrenergic receptors, it inhibits G-protein-coupled receptor signaling pathways, reducing cyclic AMP production and intracellular calcium influx. This target blockade decreases aqueous humor secretion in ocular tissue and exhibits neuroprotective effects on retinal ganglion cells under ischemic stress.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(200.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 69 mg/mL |
| Ethanol | 69 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.