CAS No. 417716-92-8

Batch: Purity:99.97
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E7080 (Lenvatinib) Chemical Structure
Chemical Structure
Check the E7080 (Lenvatinib) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide
CAS Number 417716-92-8
Molecular Formula

C21H19ClN4O4
Molecular Weight (MW) 426.85
SMILES COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl
InChIKey WOSKHXYHFSIKNG-UHFFFAOYSA-N

Ordering Information

Biological Activity

Lenvatinib (E7080) is a potent multi-target kinase inhibitor primarily targeting VEGFR2 (IC50 = and VEGFR3 (IC50 = 5.2 nM), while also inhibiting VEGFR1, FGFR1-4, PDGFR, KIT, and RET. By suppressing receptor tyrosine kinase autophosphorylation and downstream VEGF signaling pathways, it potently impairs vascular endothelial cell proliferation and tube formation. Consequently, lenvatinib inhibits angiogenesis and lymphangiogenesis, resulting in marked suppression of tumor growth and metastasis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 20 mg/mL (46.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.