CAS No. 486443-73-6

Batch: Purity:99.85
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LC3-mHTT-IN-AN1 Chemical Structure
Chemical Structure
Check the LC3-mHTT-IN-AN1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 486443-73-6
Molecular Formula

C15H9Br2NO3
Molecular Weight (MW) 411.04
SMILES C1=CC2=C(C=C1Br)C(=CC3=CC(=C(C(=C3)Br)O)O)C(=O)N2

Biological Activity

LC3-mHTT-IN-AN1 is a small-molecule autophagosome-tethering compound (ATTEC) that targets mutant huntingtin protein (mHTT) and microtubule-associated protein 1A/1B light chain 3B (LC3B). By simultaneously binding mHTT and LC3B, LC3-mHTT-IN-AN1 tethers mHTT to autophagosomes for selective autophagic degradation. This mechanism leads to allele-selective clearance of mHTT without altering wild-type huntingtin levels in cultured mouse Huntington disease neurons.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 82 mg/mL (199.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.