Lazertinib (YH25448): Selectivity & Specificity
Lazertinib (YH25448) is a potent inhibitor of EGFR Ex19del (1.7-20.6 nM), EGFR L858R (1.7-20.6 nM), EGFR T790M (1.7-20.6 nM), EGFR Ex19del/T790M (1.7-20.6 nM), EGFR L858R/T790M (1.7-20.6 nM), wild-type EGFR. Lazertinib (YH25448) exhibits the greatest inhibitory potency toward EGFR mutations (IC50 = 1.7-20.6 nM).