Lazertinib (YH25448) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

Product Name: Lazertinib (YH25448)
Catalog Number: S8724
CAS Number: 1903008-80-9
IUPAC Name: 2-Propenamide, N-[5-[[4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]-4-methoxy-2-(4-morpholinyl)phenyl]-

Relevant identified uses and uses advised against

Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

Company : Selleck Chemicals
TollFree : +1 877 796-6397
Tel : +1 832 582-8158
Fax : +1 832 582-8590

Emergency telephone number

Emergency phone #: +1 832 582-8158

2. Hazard(s) identification

Classification of the substance or mixture:

Reproductive toxicity 2 (H361): Suspected of damaging fertility or the unborn child.
Specific target organ toxicity (repeated exposure) 1 (H372): Causes damage to organs through prolonged or repeated exposure.
Acute toxicity - oral 4 (H302): Harmful if swallowed.
Sensitization - skin 1B (H317): May cause an allergic skin reaction.
Aquatic Chronic 4 (H413): May cause long lasting harmful effects to aquatic life.

Pictogram: GHS07 , GHS08

Signal word: Danger

Hazard statements:

H302: Harmful if swallowed.
H317: May cause an allergic skin reaction.
H361: Suspected of damaging fertility or the unborn child.
H372: Causes damage to organs through prolonged or repeated exposure.
H413: May cause long lasting harmful effects to aquatic life.

Precautionary statements:

P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P272: Contaminated work clothing must not be allowed out of the workplace.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection.
P301+P312: If swallowed: Call a poison center/doctor if you feel unwell.
P330: Rinse mouth.
P302+P352: If on skin: Wash with plenty of water.
P308+P313: IF exposed or concerned: Get medical advice/attention.
P321: Specific treatment (see on this label).
P314: Get medical advice/attention if you feel unwell.
P362+P364: Take off contaminated clothing and wash it before reuse.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

Classification system:

NFPA ratings (scale 0 - 4): Health = 2, Fire = 0, Reactivity = 0.
HMIS-ratings (scale 0 - 4): Health = 2, Fire = 0, Reactivity = 0.

Other hazards:
Results of PBT and vPvB assessment: Not applicable.

3. Composition/information on ingredients

Chemical characterization: Substances
CAS No. Description: 1903008-80-9
Name: 2-Propenamide, N-[5-[[4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]-4-methoxy-2-(4-morpholinyl)phenyl]-

4. First-aid measures

Description of first aid measures:

General information: Symptoms of poisoning may occur after several hours; medical observation for at least 48 hours after the accident is recommended.
After inhalation: Supply fresh air; consult a doctor in case of complaints.
After skin contact: Generally, the product does not irritate the skin.
After eye contact: Rinse opened eye for several minutes under running water.
After swallowing: Immediately call a doctor.

Most important symptoms and effects, both acute and delayed: No further relevant information available.

Indication of any immediate medical attention and special treatment needed: No further relevant information available.

5. Fire-fighting measures

Extinguishing media:

Suitable extinguishing agents: Use fire fighting measures that suit the environment. A solid water stream may be inefficient.

Special hazards arising from the substance or mixture: No further relevant information available.

Advice for firefighters:

Protective equipment: No special measures required.

6. Accidental release measures

Personal precautions, protective equipment and emergency procedures: Not required.

Environmental precautions: Do not allow to enter sewers, surface, or ground water.

Methods and material for containment and cleaning up: Dispose of contaminated material as waste according to section 13.

Reference to other sections:

See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.

7. Handling and storage

Precautions for safe handling:

No special precautions are necessary if used correctly.
Avoid breathing dust/fume/gas/mist/vapors/spray.
Avoid prolonged or repeated exposure.
Keep away from sources of ignition.
Take precautionary measures against static discharge.

Information about protection against explosions and fires: No special measures required.

Conditions for safe storage, including any incompatibilities:

Keep container tightly closed.
Store in accordance with information listed on the product insert.

8. Exposure controls/personal protection

Control parameters:

Components with limit values that require monitoring at the workplace: Not required.

Exposure controls:

Appropriate engineering controls: No further data; see section 7.
Personal protective equipment:
- General protective and hygienic measures: Keep away from foodstuffs, beverages, and feed. Wash hands before breaks and at the end of work. Store protective clothing separately.
- Breathing equipment: In case of brief exposure or low pollution, use a respiratory filter device. In case of intensive or longer exposure, use a respiratory protective device that is independent of circulating air.
- Protection of hands: Use protective gloves. The glove material must be impermeable and resistant to the product.
- Eye protection: Tightly sealed goggles.

9. Physical and chemical properties

Information on basic physical and chemical properties:

Physical state: powder
Color: Not determined.
Odor: Characteristic
Structural Formula: C30H34N8O3
Molecular Weight: 554.6 g/mol
Odor threshold: Not determined.
Melting point/Melting range: Undetermined.
Boiling point/Boiling range: Undetermined.
Flammability: Product is not flammable.
Explosion limits: Lower: Not determined; Upper: Not determined.
Flash point: Not applicable.
Decomposition temperature: Not determined.
pH-value: Not applicable.
Viscosity (Kinematic/Dynamic): Not applicable.
SOLUBILITY: DMF: 3mg/mL; DMF:PBS (pH 7.2) (1:2): 0.3mg/mL; DMSO: 0.2mg/mL
Solubility in / Miscibility with Water: Not determined.
Partition coefficient (n-octanol/water): Not determined.
Vapor pressure: Not applicable.
Density: Not determined.
Relative density: Not determined.
Vapor density: Not applicable.
Particle characteristics: Not determined.
Appearance (Form): powder
Ignition temperature: Not determined.
Danger of explosion: Product does not present an explosion hazard.
Evaporation rate: Not applicable.

10. Stability and reactivity

Reactivity: No further relevant information available.

Chemical stability:

Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.

Possibility of hazardous reactions: No dangerous reactions known.

Conditions to avoid: No further relevant information available.

Incompatible materials: Strong oxidizing agents.

Hazardous decomposition products: Carbon oxides, nitrogen oxides.

11. Toxicological information

Information on toxicological effects:

Acute toxicity: Harmful if swallowed.
Primary irritant effect:
- On the skin: No irritant effect.
- On the eye: No irritating effect.
Sensitization: No sensitizing effects known.
Additional toxicological information: No interactive effects between components are known.
Carcinogenic categories:
- IARC (International Agency for Research on Cancer): Substance is not listed.
- NTP (National Toxicology Program): Substance is not listed.
- OSHA-Ca (Occupational Safety & Health Administration): Substance is not listed.

12. Ecological information

Toxicity:

Aquatic toxicity: No further relevant information available.

Persistence and degradability: No further relevant information available.

Bioaccumulative potential: No further relevant information available.

Mobility in soil: No further relevant information available.

Results of PBT and vPvB assessment: Not applicable.

Other adverse effects:

General notes: Water hazard class 2 (Self-assessment): hazardous for water. Do not allow product to reach ground water, water course, or sewage system. Danger to drinking water if even small quantities leak into the ground.

13. Disposal considerations

Waste treatment methods:

Recommendation: Must not be disposed of together with household garbage. Do not allow product to reach sewage system.

Uncleaned packagings:

Recommendation: Disposal must be made according to official regulations.

14. Transport information

UN-Number:

DOT, IMDG, IATA: not regulated

UN proper shipping name:

DOT, IMDG, IATA: not regulated

Transport hazard class(es):

DOT, ADN, IMDG, IATA Class: not regulated

Packing group:

DOT, IMDG, IATA: not regulated

Environmental hazards: Not applicable.

Special precautions for user: Not applicable.

Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code: Not applicable.

UN "Model Regulation": not regulated

15. Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
· Sara
· Section 355 (extremely hazardous substances):Substance is not listed.
· Section 313 (Specific toxic chemical listings):Substance is not listed.
· TSCA (Toxic Substances Control Act):Substance is not listed.
· Hazardous Air PollutantsSubstance is not listed.
· Chemicals known to cause cancer:Substance is not listed.
· Chemicals known to cause reproductive toxicity for females:Substance is not listed.
· Chemicals known to cause reproductive toxicity for males:Substance is not listed.
· Chemicals known to cause developmental toxicity:Substance is not listed.
· Carcinogenic categories
· EPA (Environmental Protection Agency)Substance is not listed.
· TLV (Threshold Limit Value)Substance is not listed.
· NIOSH-Ca (National Institute for Occupational Safety and Health)Substance is not listed.
· Chemical safety assessment:A Chemical Safety Assessment has not been carried out.

16. OTHER INFORMATION

Revision Date: 2026/07/17
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.