Synonyms: ZIP6, SLC39A6
Ladiratuzumab (Anti-LIV-1 / SLC39A6) is an anti-LIV-1/ZIP6 humanized monoclonal antibody. MW: 145.5 kD.
| Featured Inhibitors | Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933 |
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| Description |
Ladiratuzumab (Anti-LIV-1 / SLC39A6) is an anti-LIV-1/ZIP6 humanized monoclonal antibody. MW: 145.5 kD.
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| CAS No. | 1629760-28-6 |
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| Molecular Weight | 145.5 kDa |
| Isotype | Human IgG1 |
| Source | CHO |
| Purification | AKTA |
| Sterility | 0.2 μM filtered |
| Formulation | 100 mM Pro-Ac, 20mM Arg, pH5.0 |
| Storage (From the date of receipt) |
Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. |
*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT03310957 | COMPLETED | Drug: ladiratuzumab vedotin|Drug: Pembrolizumab | Triple Negative Breast Neoplasms | Seagen Inc. | 2018-02-27 | PHASE1; PHASE2 |
| NCT04032704 | TERMINATED | Drug: ladiratuzumab vedotin|Drug: pembrolizumab | Small Cell Lung Cancer; Non-small Cell Lung Cancer, Squamous; Non-small Cell Lung Cancer, Non-squamous; Head and Neck Squamous Cell Carcinoma; Esophageal Squamous Cell Carcinoma; Gastric Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma; Prostate Cancer; Melanoma | Seagen Inc. | 2019-10-09 | PHASE2 |
| NCT01969643 | COMPLETED | Drug: ladiratuzumab vedotin|Drug: Trastuzumab | HER2 Positive Breast Neoplasms; Hormone Receptor Positive Breast Neoplasms; Triple Negative Breast Neoplasms; HER2 Mutations Breast Neoplasms | Seagen Inc. | 2013-10-22 | PHASE1 |
(data from https://clinicaltrials.gov, updated on 2025-12-12)
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