CAS No. 159182-43-1
| IUPAC Name | 1-hexyl-3-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]urea | |
|---|---|---|
| CAS Number | 159182-43-1 | |
| Molecular Formula |
C30H40N4O6S |
|
| Molecular Weight (MW) | 584.73 | |
| SMILES | CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O | |
| InChIKey | NYYJKMXNVNFOFQ-MHZLTWQESA-N |
L755507 is a potent and selective β3 adrenergic receptor partial agonist that significantly enhances CRISPR/Cas9-mediated homology-directed repair (HDR) efficiency. By modulating cellular repair pathways to favor HDR over non-homologous end joining, L755507 facilitates precise genome editing and targeted knock-ins in human induced pluripotent stem cells (iPSCs) and primary mammalian cells, providing a valuable tool for knock-in applications and gene therapy research. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(171.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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