CAS No. 51298-62-5

Batch: Purity:99.94
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L-NAME HCl Chemical Structure
Chemical Structure
Check the L-NAME HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoate;hydrochloride
CAS Number 51298-62-5
Molecular Formula

C7H15N5O4.HCl
Molecular Weight (MW) 269.69
SMILES COC(=O)C(CCCN=C(N)N[N+](=O)[O-])N.Cl
InChIKey QBNXAGZYLSRPJK-JEDNCBNOSA-N

Ordering Information

Biological Activity

L-NAME HCl is a nonselective inhibitor of nitric oxide synthase (NOS) isoforms, targeting bovine nNOS (Ki =, human eNOS (Ki =, and murine iNOS (Ki =. By inhibiting NOS activity, it blocks nitric oxide production, leading to vasoconstriction and increased vascular resistance. Consequently, L-NAME HCl is widely utilized as a pharmacological tool to induce animal models of hypertension. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 54 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.