CAS No. 142-47-2

Batch: Purity:99.62
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L-Glutamic acid monosodium salt Chemical Structure
Chemical Structure
Check the L-Glutamic acid monosodium salt product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 142-47-2
Molecular Formula

C5H8NO4.Na
Molecular Weight (MW) 169.11
SMILES C(CC(=O)O)C(C(=O)[O-])N.[Na+]

Ordering Information

Biological Activity

L-Glutamic acid monosodium salt is a major excitatory neurotransmitter and an endogenous agonist across all subtypes of glutamate receptors, including metabotropic, NMDA, AMPA, and kainate receptors. Receptor activation by L-glutamate modulates excitatory synaptic transmission and neuronal excitability throughout the central nervous system. Furthermore, glutamate signaling stimulates dopamine release from dopaminergic nerve terminals, influencing synaptic plasticity and downstream neuronal signaling pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 33 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.