CAS No. 490-83-5

Batch: Purity:99.50
Check CoA
(L)-Dehydroascorbic acid Chemical Structure
Chemical Structure
Check the (L)-Dehydroascorbic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (5R)-5-[(1S)-1,2-dihydroxyethyl]oxolane-2,3,4-trione
CAS Number 490-83-5
Molecular Formula

C6H6O6
Molecular Weight (MW) 174.11
SMILES OCC(O)C1OC(=O)C(=O)C1=O
InChIKey SBJKKFFYIZUCET-JLAZNSOCSA-N

Ordering Information

Biological Activity

(L)-Dehydroascorbic acid (DHA) is an oxidized form of L-ascorbic acid that acts as a substrate for facilitative glucose transporters (GLUTs). Upon cellular transport via GLUT1, DHA undergoes intracellular reduction to ascorbic acid, depleting glutathione and accumulating reactive oxygen species, which inhibits glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and disrupts glycolytic flux to mediate selective cytotoxicity in KRAS-mutant cancer cells. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 35 mg/mL (201.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.