CAS No. 4350-09-8
Batch:
Purity:99.93
Chemical Structure
Check the
L-5-Hydroxytryptophan
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 4350-09-8 | |
|---|---|---|
| Molecular Formula |
C11H12N2O3 |
|
| Molecular Weight (MW) | 220.22 |
L-5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid precursor and intermediate in the biosynthesis of the neurotransmitter serotonin. As an immediate biochemical precursor, 5-HTP readily crosses the blood-brain barrier and is decarboxylated to serotonin (5-hydroxytryptamine, 5-HT) by aromatic L-amino acid decarboxylase. Increased central serotonin levels modulate downstream neurochemical signaling, influencing mood regulation, sleep architecture, and neurological homeostasis. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
375 mg/mL
(1702.84 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 2 mg/mL |
| Ethanol | Insoluble |
| DMSO |
16 mg/mL
(72.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.