CAS No. 1272719-00-2

Batch: Purity:99.65
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Pyrilutamide (KX-826) Chemical Structure
Chemical Structure
Check the Pyrilutamide (KX-826) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[3-[4-cyano-2-fluoro-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluoro-N-methylbenzamide
CAS Number 1272719-00-2
Molecular Formula

C21H15F5N4O2S
Molecular Weight (MW) 482.43
InChIKey CGRMNGGGSWLDDC-UHFFFAOYSA-N

Ordering Information

Biological Activity

Pyrilutamide (KX-826) is a small-molecule antagonist of the androgen receptor (AR) designed as a topical therapeutic agent. By locally inhibiting androgen binding to AR within dermal papilla cells, it attenuates androgenic signaling pathways without systemic hormone suppression. This targeted AR antagonism prevents dihydrotestosterone-mediated follicular miniaturization, supporting hair follicle retention and growth in androgenetic alopecia.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 96 mg/mL (198.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 24 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.