CAS No. 1021497-97-1
Batch:
Purity:99.8
Chemical Structure
Check the
KR-33494
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[[2-(4-bromophenyl)sulfanylacetyl]amino]-1-(2-phenylethyl)pyrazole-3-carboxylic acid | |
|---|---|---|
| CAS Number | 1021497-97-1 | |
| Molecular Formula |
C20H18BrN3O3S |
|
| Molecular Weight (MW) | 460.34 | |
| SMILES | OC(=O)C1=N[N](CCC2=CC=CC=C2)C=C1NC(=O)CSC3=CC=C(Br)C=C3 | |
| InChIKey | ZRLJEHIUGYTTSZ-UHFFFAOYSA-N |
KR-33494 is a small-molecule inhibitor targeting FAS-associated factor 1 (FAF1) to block Fas-mediated apoptotic cell death pathways. By interfering with FAF1 function, KR-33494 inhibits downstream apoptotic signaling cascades and prevents cell death triggered by oxidative stress or ischemic injury. Probe derivatives of KR-33494 facilitate molecular studies of FAF1 binding interactions and death receptor-mediated cell death pathways. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(199.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.