CAS No. 182004-65-5
Batch:
Purity:99.86
Chemical Structure
Check the
KB-R7943 mesylate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | methanesulfonic acid;2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl carbamimidothioate | |
|---|---|---|
| CAS Number | 182004-65-5 | |
| Molecular Formula |
C17H21N3O6S2 |
|
| Molecular Weight (MW) | 427.5 | |
| SMILES | C[S](O)(=O)=O.NC(=N)SCCC1=CC=C(OCC2=CC=C(C=C2)[N+]([O-])=O)C=C1 | |
| InChIKey | WGIKEBHIKKWJLG-UHFFFAOYSA-N |
KB-R7943 mesylate is an inhibitor of the reverse Na+/Ca2+ exchanger (NCX(rev)) with an IC50 of. Blockade of reverse Na+/Ca2+ exchange disrupts intracellular calcium ion transport and downstream pathway regulation, promoting activation of the JNK signaling pathway and inhibition of autophagic flux to induce cell death in prostate cancer cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(201.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.