CAS No. 2416874-75-2
| IUPAC Name | trans-(1S,3S)-3-N-(5-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine;dihydrochloride | |
|---|---|---|
| CAS Number | 2416874-75-2 | |
| Molecular Formula |
C16H25N5.2ClH |
|
| Molecular Weight (MW) | 360.33 | |
| SMILES | Cl.Cl.CCC(CC)C1=NC2=CC=N[N]2C(=C1)NC3CCC(N)C3 | |
| InChIKey | OTUPXOLLHVLWQF-NJHZPMQHSA-N |
KB-0742 Dihydrochloride is a potent, selective, and orally bioavailable small-molecule inhibitor of the transcription elongation cofactor CDK9. By targeting the CDK9/cyclin T1 complex, it suppresses RNA polymerase II-mediated transcription elongation, leading to the rapid downregulation of oncogenic transcription factors such as MYC. Consequently, CDK9 inhibition impairs cancer cell proliferation and induces apoptosis in transcriptionally addicted tumor models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 72 mg/mL |
| Ethanol | 72 mg/mL |
| DMSO |
72 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 72 mg/mL |
| Ethanol | 6 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- KB-0742 Dihydrochloride Clinical Trials
- KB-0742 Dihydrochloride Solubility in DMSO
- KB-0742 Dihydrochloride Stock Solution
- KB-0742 Dihydrochloride Storage
- KB-0742 Dihydrochloride Stability
- KB-0742 Dihydrochloride Molecular Weight
- KB-0742 Dihydrochloride SMILES
- KB-0742 Dihydrochloride Chemical Structure (2D and 3D)
- KB-0742 Dihydrochloride SDS｜MSDS