CAS No. 217094-32-1

Batch: Purity:99.64
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K-604 dihydrochloride Chemical Structure
Chemical Structure
Check the K-604 dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[4-[2-(1H-benzimidazol-2-ylsulfanyl)ethyl]piperazin-1-yl]-N-[6-methyl-2,4-bis(methylsulfanyl)-3-pyridinyl]acetamide;dihydrochloride
CAS Number 217094-32-1
Molecular Formula

C23H30N6OS3.2ClH
Molecular Weight (MW) 539.18
InChIKey DEKWEGUBUYKTAV-UHFFFAOYSA-N

Ordering Information

Biological Activity

K-604 dihydrochloride is a potent, selective inhibitor of human ACAT-1 (IC50 0.45 μM) over human ACAT-2 (IC50 102.85 μM), exhibiting 229-fold selectivity with a Ki of 0.378 μM. It suppresses macrophage cholesterol esterification (IC50 68.0 nM) and enhances cholesterol efflux. Consequently, K-604 blocks foam cell accumulation and attenuates fatty streak lesion formation in vivo without altering plasma cholesterol levels. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (185.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 3 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.