CAS No. 1210004-12-8
Batch:
Purity:99.99
Chemical Structure
Check the
JZL195
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate | |
|---|---|---|
| CAS Number | 1210004-12-8 | |
| Molecular Formula |
C24H23N3O5 |
|
| Molecular Weight (MW) | 433.46 | |
| SMILES | C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC4=CC=C(C=C4)[N+](=O)[O-] | |
| InChIKey | QNYRAEKLMNDRFY-UHFFFAOYSA-N |
JZL195 is a potent dual inhibitor of fatty acid amide hydrolase (FAAH) (IC50 2 nM) and monoacylglycerol lipase (MAGL). By simultaneously blocking FAAH and MAGL, JZL195 prevents the degradation of anandamide and 2-arachidonoylglycerol, leading to elevated endocannabinoid levels in the central nervous system. This dual target inhibition potentiates endocannabinoid signaling, resulting in enhanced antinociceptive effects and modulating neurological responses. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
43 mg/mL
(99.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.