CAS No. 244218-51-7

Batch: Purity:99.94
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JTC-801 Chemical Structure
Chemical Structure
Check the JTC-801 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(4-amino-2-methylquinolin-6-yl)-2-[(4-ethylphenoxy)methyl]benzamide;hydrochloride
CAS Number 244218-51-7
Molecular Formula

C26H25N3O2.HCl
Molecular Weight (MW) 447.96
SMILES CCC1=CC=C(C=C1)OCC2=CC=CC=C2C(=O)NC3=CC4=C(C=C(N=C4C=C3)C)N.Cl
InChIKey NQLIYKXNAXKMBL-UHFFFAOYSA-N

Biological Activity

JTC-801 is a novel, selective opioid receptor-like 1 (ORL1) receptor antagonist with a Ki of. By blocking ORL1 receptor activation, the compound antagonizes nociceptin-mediated inhibition of forskolin-induced cyclic AMP accumulation and suppresses downstream pain signaling pathways. Consequently, JTC-801 exhibits marked anti-nociceptive and anti-allodynic responses in vivo across various acute and inflammatory pain models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 90 mg/mL (200.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 31 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Yamada H, et al. Br J Pharmacol. 2002;135(2):323-32.

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Note: Technical data last updated: Sep 1, 2026.