CAS No. 749886-87-1
Batch:
Purity:99.58
Chemical Structure
Check the
JSH-23
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine | |
|---|---|---|
| CAS Number | 749886-87-1 | |
| Molecular Formula |
C16H20N2 |
|
| Molecular Weight (MW) | 240.34 | |
| SMILES | CC1=CC(=C(C=C1)NCCCC2=CC=CC=C2)N | |
| InChIKey | YMFNPBSZFWXMAD-UHFFFAOYSA-N |
JSH-23 is an inhibitor of NF-κB transcriptional activity that inhibits LPS-stimulated NF-κB transcriptional activity with an IC50 of 7.1 μM in RAW 264.7 macrophages. Mechanistically, JSH-23 selectively interferes with LPS-induced NF-κB nuclear translocation without affecting IκB degradation, thereby inhibiting downstream pro-inflammatory gene expression and inflammatory phenotypes mediated by the NF-κB signaling pathway. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
48 mg/mL
(199.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 16 mg/mL |
| Water | Insoluble |
| DMSO |
48 mg/mL
(199.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.