CAS No. 2115701-93-2
Batch:
Purity:98.92
Chemical Structure
Check the
(+)-JQ1 PA
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-prop-2-ynylacetamide | |
|---|---|---|
| CAS Number | 2115701-93-2 | |
| Molecular Formula |
C22H20ClN5OS |
|
| Molecular Weight (MW) | 437.95 | |
| SMILES | CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NCC#C)N=C2C4=CC=C(Cl)C=C4)C | |
| InChIKey | ZLSCJWMPQYKVKU-KRWDZBQOSA-N |
(+)-JQ1 PA is a photoaffinity probe derivative of (+)-JQ1, a potent and selective inhibitor of bromodomain and extra-terminal (BET) family proteins, including BRD2, BRD3, and BRD4. By competitively binding to BET bromodomains, it displaces BET proteins from chromatin and acetylated histones, disrupting transcriptional regulation, downregulating MYC expression, and suppressing cell proliferation in various cancer cell lines. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
88 mg/mL
(200.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 88 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.