CAS No. 2086772-26-9

Batch: Purity:99.95
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Onametostat (JNJ-64619178) Chemical Structure
Chemical Structure
Check the Onametostat (JNJ-64619178) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,2R,3S,5R)-3-[2-(2-amino-3-bromoquinolin-7-yl)ethyl]-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
CAS Number 2086772-26-9
Molecular Formula

C22H23BrN6O2
Molecular Weight (MW) 483.36
SMILES C1C(C(C(C1N2C=CC3=C(N=CN=C32)N)O)O)CCC4=CC5=NC(=C(C=C5C=C4)Br)N
InChIKey DBSMLQTUDJVICQ-CJODITQLSA-N

Ordering Information

Biological Activity

Onametostat (JNJ-64619178) is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor targeting the PRMT5-MEP50 complex. By suppressing PRMT5-mediated symmetric dimethylation of arginine residues on substrate proteins, Onametostat disrupts RNA splicing machinery and downstream oncogenic signaling pathways. This targeted inhibition effectively impairs tumor cell proliferation and induces apoptosis in PRMT5-dependent cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (206.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.